Search results for "Acanthamoeba polyphaga"

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Mimiviruses and the Human Interferon System: Viral Evasion of Classical Antiviral Activities, But Inhibition By a Novel Interferon-β Regulated Immuno…

2017

International audience; In this review we discuss the role of mimiviruses as potential human pathogens focusing on clinical and evolutionary evidence. We also propose a novel antiviral immunomodulatory pathway controlled by interferon-beta (IFN-beta) and mediated by immune-responsive gene 1 (IRG1) and itaconic acid, its product. Acanthamoeba polyphaga Mimivirus (APMV) was isolated from amoebae in a hospital while investigating a pneumonia outbreak. Mimivirus ubiquity and role as protist pathogens are well understood, and its putative status as a human pathogen has been gaining strength as more evidence is being found. The study of APMV and human cells interaction revealed that the virus is …

0301 basic medicineCarboxy-LyasesImmunologyHuman pathogenVirusImmunomodulation03 medical and health sciences[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesInterferon βInterferonVirologymedicineAnimalsHumansGiant VirusGenetic Predisposition to DiseaseGeneMimivirusbiologyProteinsSuccinatesCell BiologyInterferon-betabiology.organism_classificationVirologyDNA Virus Infections3. Good health030104 developmental biologyAcanthamoeba polyphagaHost-Pathogen InteractionsInterferonsMimiviridaemedicine.drugSignal TransductionJournal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research

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PEPhysical Sciences and Engineering
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LSLife Sciences
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